By A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)

ISBN-10: 1468437348

ISBN-13: 9781468437348

ISBN-10: 1468437364

ISBN-13: 9781468437362

The challenge of senescence, as mirrored within the historical past of reli­ gion and philosophy, has lengthy been one of many maximum issues of humankind. against this, gerontology as a department of technology remains to be relatively younger. in the past decade, concomitant with quick growth in our figuring out of the fundamental existence sciences, significant shops of data approximately organic getting older were accrued. this information, even if, bobbing up from many clinical disciplines and fascinated with various degrees of biologic association, turns out nearly random and covers every little thing from molecules to human societies. Theories complex to interpret the evidence and to appreciate the mech­ anisms fascinated about senescence have remained in person, instead of normal, territories. It has lengthy been felt via a few gerontologists that it was once time for a number of the experts to step again and take a generalist view of gerontology, to reassess and reevaluate the culmination in their analyt­ ical ambitions at various degrees inside a broader context. a few others might imagine it nonetheless untimely. It appeared, despite the fact that, that almost all of these who accumulated in Tokyo at the party of the XIth foreign Congress of Gerontology have been of the opinion that there has been a lot to be received in trying to find interrelationships one of the proof and theories originated within the diverse degrees of investiga­ tion in an try to become aware of and get pleasure from the organic drama of senescence as an entity.

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Additional info for Aging Phenomena: Relationships among Different Levels of Organization

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Loss of responsiveness by normal cells concomitant with an increase in doubling experiences provides an explanation for cellular aging in vitro and probably in vivo. Future studies should focus on mechanisms for this decline in responsiveness by normal cells to growth factors. REFERENCES 1• 2. 3. 4. 5. 6. 7. 8. L. Hayflick and P. S. Moorehead, The serial cultivation of human diploid cell strains, Exp. Cell Res. 25:585, 1961. L. Hayflick, The limited in vitro lifetime of human diploid cell strains, ~ Cell Res:-37:614, 1965.

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Aging Phenomena: Relationships among Different Levels of Organization by A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)

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